Humanized mouse model could significantly improve preclinical research on drugs for celiac disease
Celiac disease is an autoimmune disorder in which the immune system reacts to gluten. Destaque: 1%, 30%.
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Scientists uncover drivers of recurrent arthritis after immunotherapy, suggesting potential biomarkers
A new study led by researchers at The University of Texas MD Anderson Cancer Center has shown that inflammatory arthritis occurring as a side effect of immune checkpoint inhibitors behaves like an immune-memory disease, suggesting that certain immune cell populations could serve
Key genetic differences between pediatric and adult forms of immune-mediated inflammatory diseases identified
Researchers from Children's Hospital of Philadelphia (CHOP) have found that pediatric-onset rheumatic and inflammatory diseases have distinct genetic architecture compared with those in adults.
Immune 'reprogramming' could protect poultry from deadly diseases without antibiotics
University of Bristol–led researchers have identified a naturally occurring gut molecule that could strengthen chickens' immune response against a wide range of bacterial infections. This development, published today, Aug. 12, in The Journal of Immunology, offers a major step for
Immune cells rely on a cholesterol sensor to maintain balance, researchers discover
Every day, billions of cells in our body die and are removed as part of normal tissue maintenance.
Differences in immune cells predict skin cancer treatment outcomes
In a first-of-its-kind study by King's College London, researchers have linked changes in two major types of immune cells in blood to different survival outcomes for patients with melanoma.
Protein secreted by immune cells may help drive brain aging
Brain-resident immune cells that have reached an old-age state called "senescence" secrete a protein that causes dysfunction in other brain cells, according to a study led by investigators at Weill Cornell Medicine.
Heart surgery cured a man’s skin cancer – and gave him a bee allergy
Having surgery for a heart condition is thought to have triggered an immune response that put the patient into remission for his severe skin cancer, but also caused him to develop a serious allergy to bee stings.
Sarcoidosis shifts lung immune-cell communication, single-cell data suggest
Researchers at National Jewish Health and partner institutions have discovered specific changes in immune cells in the lungs of people with sarcoidosis.
Brain immune cell map explains how defenses shift during Alzheimer's progression
The brain's immune cells are increasingly recognized as key players in Alzheimer's disease, but exactly how they change as the disease develops has remained unclear. A new study published in Nature Genetics provides the most comprehensive map to date of these cells, identifying a
HIV-1 proviruses may drive chronic systemic inflammation
HIV (human immunodeficiency virus) is a virus that attacks the body's immune system and remains a major global health challenge because of persistent viral reservoirs, despite effective treatments. Key factors include around 40 million people living with HIV, 1 million new infect
AI model maps tumor tissue to improve cancer care
A tumor is more than its cancer cells. Immune cells, blood vessels and other surrounding tissue influence how a cancer grows and responds to treatment. Two tumors containing the same cell types can respond very differently to the same therapy depending on how those cells are arra